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Autism and major depressive disorder (MTAG)

BEND4 · rs16854048

Where this position leads

Condition: Major Depressive Disorder

rs16854048 Condition: Major Depressive Disorder Major Depressive Disorder Condition rs16854048 rs16854048 BEND4

What the study found

Who was studied 18,381 European ancestry autism cases, 27,969 European ancestry controls, 111,902 major depression cases, 312,113 controls.

The effect Each copy of the A allele shifted the measure 0.069 higher (95% confidence interval 0.045-0.093); p = 1 × 10−8.

How common The A allele had a frequency of about 86% in the people studied.

Where it sits Chromosome 4, band 4p13 — in an intron of BEND4.

What each result means

A/A Two copies of the version the research linked to Autism and major depressive disorder (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Autism and major depressive disorder (MTAG). That is a smaller link than two copies.
C/C No copy of the version the research linked to Autism and major depressive disorder (MTAG). This is the starting point the study compared everyone against.
Source
Identification of common genetic risk variants for autism spectrum disorder
Grove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, Pallesen J, Agerbo E, Andreassen OA, Anney R, Awashti S, Belliveau R
and 65 more — show all
Bettella F, Buxbaum JD, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Christensen JH, Churchhouse C, Dellenvall K, Demontis D, De Rubeis S, Devlin B, Djurovic S, Dumont AL, Goldstein JI, Hansen CS, Hauberg ME, Hollegaard MV, Hope S, Howrigan DP, Huang H, Hultman CM, Klei L, Maller J, Martin J, Martin AR, Moran JL, Nyegaard M, Nyegaard M, Nærland T, Palmer DS, Palotie A, Pedersen CB, Pedersen MG, dPoterba T, Poulsen JB, Pourcain BS, Qvist P, Rehnström K, Reichenberg A, Reichert J, Robinson EB, Roeder K, Roussos P, Saemundsen E, Sandin S, Satterstrom FK, Davey Smith G, Stefansson H, Steinberg S, Stevens CR, Sullivan PF, Turley P, Walters GB, Xu X, Stefansson K, Geschwind DH, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Neale BM, Daly MJ, Børglum AD
Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium · BUPGEN · Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium · 23andMe Research Team
Nature genetics · 2019 · PMID 30804558

Questions about rs16854048

What is rs16854048?

rs16854048 is a single position in the genome, in or near the BEND4 gene. Published research associates it with autism and major depressive disorder (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs16854048 linked to?

On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs16854048 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs16854048 come from?

GWAS Catalog, Nature genetics 2019, PMID:30804558. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Autism and major depressive disorder (MTAG) (rs16854048). MyGeneLog™. https://www.mygenelog.com/variants/rs16854048

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