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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
2 / 4
Its strongest genetic-study result is p = 10−21, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 114,580 African American or Afro-Caribbean individuals, 55,712 Hispanic or Latin American individuals, 5,942 East Asian ancestry individuals, 406,601 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0489 lower (95% confidence interval 0.039-0.059); p = 3 × 10−21.
How common The A allele had a frequency of about 92% in the people studied.
Where it sits Chromosome 3, band 3q26.2 — in an intron of MECOM.
What each result means
A/ATwo copies of the version the research linked to platelet count (maximum, inv-norm transformed). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to platelet count (maximum, inv-norm transformed). That is a smaller link than two copies.
G/GNo copy of the version the research linked to platelet count (maximum, inv-norm transformed). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs16853226
What is rs16853226?
rs16853226 is a single position in the genome, in or near the MECOM gene. Published research associates it with platelet count (maximum, inv-norm transformed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs16853226 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs16853226 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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