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Chronic elevation of alanine aminotransferase (cALT) levels

RORA-AS1 · rs168144

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 95,472 European ancestry cases, 68,725 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.052 lower (95% confidence interval 0.038-0.066); p = 3 × 10−12.

How common The C allele had a frequency of about 43% in the people studied.

Where it sits Chromosome 15, band 15q22.2 — in an intron of RORA-AS1.

What each result means

C/C Two copies of the version the research linked to Chronic elevation of alanine aminotransferase (cALT) levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Chronic elevation of alanine aminotransferase (cALT) levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Chronic elevation of alanine aminotransferase (cALT) levels. This is the starting point the study compared everyone against.
Source
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J
and 78 more — show all
Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Creasy KT, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA, Rader DJ, Voight BF, Chang KM
Regeneron Genetics Center · Geisinger-Regeneron DiscovEHR Collaboration · EPoS Consortium · VA Million Veteran Program
Nature genetics · 2022 · PMID 35654975

Questions about rs168144

What is rs168144?

rs168144 is a single position in the genome, in or near the RORA-AS1 gene. Published research associates it with chronic elevation of alanine aminotransferase (calt) levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs168144 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs168144 come from?

GWAS Catalog, Nature genetics 2022, PMID:35654975. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronic elevation of alanine aminotransferase (cALT) levels (rs168144). MyGeneLog™. https://www.mygenelog.com/variants/rs168144

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