Standard

Refractive error

PRSS56 · rs1656404

Where this position leads

Condition: Myopia

rs1656404 Condition: Myopia Myopia Condition rs1656404 rs1656404 PRSS56

What the study found

Who was studied 37,382 European ancestry individuals, 3,995 Chinese ancestry individuals, 2,273 Malay ancestry individuals, 2,108 Indian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.153 lower (95% confidence interval 0.11-0.20); p = 8 × 10−11.

How common The A allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 2, band 2q37.1 — between genes, 5.2 kb from PRSS56.

What each result means

A/A Two copies of the version the research linked to Refractive error. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Refractive error. That is a smaller link than two copies.
G/G No copy of the version the research linked to Refractive error. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1656404

What is rs1656404?

rs1656404 is a single position in the genome, in or near the PRSS56 gene. Published research associates it with refractive error. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1656404 linked to?

On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1656404?

Subjects that appear in the title or abstract of the same papers as this rsID include short-sightedness and screens (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1656404 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1656404 come from?

GWAS Catalog, Nat Genet 2013, PMID:23396134. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Refractive error (rs1656404). MyGeneLog™. https://www.mygenelog.com/variants/rs1656404

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