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Psoriasis

POLR1HASP · rs1655901

Where this position leads

Condition: Psoriasis

rs1655901 Condition: Psoriasis Psoriasis Condition rs1655901 rs1655901 POLR1HASP

What the study found

Who was studied 394,626 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.231 higher (95% confidence interval 0.19-0.27); p = 2 × 10−67.

How common The C allele had a frequency of about 56% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — in the 3′ untranslated region of POLR1HASP.

What each result means

C/C Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
T/T No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs1655901

What is rs1655901?

rs1655901 is a single position in the genome, in or near the POLR1HASP gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1655901 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs1655901 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1655901 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs1655901). MyGeneLog™. https://www.mygenelog.com/variants/rs1655901

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