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Who was studied 2,636 African ancestry cases, 10,193 African ancestry controls, 21,468 European ancestry cases, 105,974 European ancestry controls.
The effect
Each copy of the T allele carried 1.08 times the odds of Breast cancer (estrogen-receptor negative) (95% confidence interval 1.05-1.11); p = 1 × 10−8.
How common The T allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 7, band 7q11.23 — between genes, 20.3 kb from CASTOR2.
What each result means
C/CNo copy of the version the research linked to Breast cancer (estrogen-receptor negative). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Breast cancer (estrogen-receptor negative). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Breast cancer (estrogen-receptor negative). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2021 · PMID 34234117 · open access
Questions about rs1637365
What is rs1637365?
rs1637365 is a single position in the genome, in or near the near CASTOR2 gene. Published research associates it with breast cancer (estrogen-receptor negative). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1637365 linked to?
On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs1637365 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1637365 come from?
GWAS Catalog, Nature communications 2021, PMID:34234117. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 7223Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot2Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Breast cancer (estrogen-receptor negative) (rs1637365). MyGeneLog™. https://www.mygenelog.com/variants/rs1637365