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Nonsyndromic cleft lip with or without cleft palate

TANC2 · rs1588366

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 154 African ancestry cases, 274 African ancestry controls, 445 Asian ancestry cases, 1,246 Asian ancestry controls, 569 European ancestry cases, 2,704 European ancestry controls, 1,050 Central and South American cases, 2,988 Central and South American controls, 3 cases, 14 controls.

The effect Each copy of the G allele shifted the measure 0.24 lower (95% confidence interval 0.14-0.34); p = 1 × 10⁻⁸.

Where it sits Chromosome 17, band 17q23.2 — in an intron of TANC2.

What each result means

A/A No copy of the version the research linked to Nonsyndromic cleft lip with or without cleft palate. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Nonsyndromic cleft lip with or without cleft palate. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Nonsyndromic cleft lip with or without cleft palate. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-Wide Association Study of Non-syndromic Orofacial Clefts in a Multiethnic Sample of Families and Controls Identifies Novel Regions

Mukhopadhyay N, Feingold E, Moreno-Uribe L, Wehby G, Valencia-Ramirez LC, Muñeton CPR, Padilla C, Deleyiannis F, Christensen K, Poletta FA, Orioli IM, Hecht JT

and 9 more — show all

Buxó CJ, Butali A, Adeyemo WL, Vieira AR, Shaffer JR, Murray JC, Weinberg SM, Leslie EJ, Marazita ML

Frontiers in cell and developmental biology · 2021 · PMID 33898419 · open access

Questions about rs1588366

What is rs1588366?

rs1588366 is a single position in the genome, in or near the TANC2 gene. Published research associates it with nonsyndromic cleft lip with or without cleft palate. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1588366 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1588366 come from?

GWAS Catalog, Frontiers in cell and developmental biology 2021, PMID:33898419. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Nonsyndromic cleft lip with or without cleft palate (rs1588366). MyGeneLog™. https://www.mygenelog.com/variants/rs1588366

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