Gene Knowledge Graph
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Sensitive

Metabolic syndrome

near LPL · rs1581675

Where this position leads

Condition: Metabolic Syndrome

rs1581675 Condition: Metabolic Syndrome Metabolic Syndrome Condition rs1581675 rs1581675 near LPL

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−32, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 24,171 Taiwanese ancestry cases, 83,059 Taiwanese ancestry controls.

The effect Each copy of the T allele shifted the measure 0.161 lower (95% confidence interval 0.13-0.19); p = 6 × 10−33.

How common The T allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 8, band 8p21.3 — between genes, 33.7 kb from LPL.

What each result means

A/A No copy of the version the research linked to Metabolic syndrome. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Metabolic syndrome. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Metabolic syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population
Ho CY, Lee JI, Huang SP, Chen SC, Geng JH
Nutrients · 2023 · PMID 38201907 · open access

Questions about rs1581675

What is rs1581675?

rs1581675 is a single position in the genome, in or near the near LPL gene. Published research associates it with metabolic syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1581675 linked to?

On MyGeneLog this position is linked to Metabolic Syndrome. The research behind each link, and its sources, are set out on that condition page.

Does having rs1581675 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1581675 come from?

GWAS Catalog, Nutrients 2023, PMID:38201907. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Metabolic syndrome (rs1581675). MyGeneLog™. https://www.mygenelog.com/variants/rs1581675

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