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Body mass index

LRFN2 · rs1579557

Where this position leads

Conditions: Waist-to-Hip Ratio (Body Fat Distribution), Obesity and Body Weight

rs1579557 Condition: Waist-to-Hip Ratio (Body Fat Distribution) Waist-to-Hip Ratio (Body Fat Distri… Condition Condition: Obesity and Body Weight Obesity and Body Weight Condition rs1579557 rs1579557 LRFN2

What the study found

Who was studied 434,794 European ancestry female individuals.

The effect Each copy of the T allele shifted the measure 0.0206 higher (95% confidence interval 0.017-0.024); p = 2 × 10−28.

How common The T allele had a frequency of about 29% in the people studied.

Where it sits Chromosome 6, band 6p21.2 — in an intron of LRFN2.

What each result means

C/C No copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Body mass index. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1579557

What is rs1579557?

rs1579557 is a single position in the genome, in or near the LRFN2 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1579557 linked to?

On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution), Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs1579557 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1579557 come from?

GWAS Catalog, Hum Mol Genet 2018, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Body mass index (rs1579557). MyGeneLog™. https://www.mygenelog.com/variants/rs1579557

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