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Generalized epilepsy with febrile seizures plus, type 2

SCN1A · rs1574266328

Where this position leads

Condition: Febrile Seizures

rs1574266328 Condition: Febrile Seizures Febrile Seizures Condition rs1574266328 rs1574266328 SCN1A

Strength of the evidence

There is no record yet to score this position by (a ClinVar disease classification or a genome-wide significant study). That is not the same as weak evidence.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Uncertain significance for Developmental and epileptic encephalopathy; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2021-08-31. ClinVar record 655780 NM_001165963.4(SCN1A):c.725A>T (p.Gln242Leu)

Classification Likely pathogenic for Generalized epilepsy with febrile seizures plus, type 2; criteria provided, single submitter (1 of 4 stars, 1 submitter). ClinVar record 995993 NM_001165963.4(SCN1A):c.725A>G (p.Gln242Arg)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Two copies of the version ClinVar lists as likely disease-causing for Generalized epilepsy with febrile seizures plus, type 2. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. So far only one lab has made this call, so it may change. (ClinVar VCV000995993, criteria provided, single submitter)
C/T One copy of the version ClinVar lists as likely disease-causing for Generalized epilepsy with febrile seizures plus, type 2. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. So far only one lab has made this call, so it may change. (ClinVar VCV000995993, criteria provided, single submitter)
T/T No copy of the version ClinVar lists as likely disease-causing for Generalized epilepsy with febrile seizures plus, type 2. This is the usual result. So far only one lab has made this call, so it may change. (ClinVar VCV000995993, criteria provided, single submitter)

Source: ClinVar VCV000995993, criteria provided, single submitter

Questions about rs1574266328

What is rs1574266328?

rs1574266328 is a single position in the genome, in or near the SCN1A gene. Published research associates it with generalized epilepsy with febrile seizures plus, type 2. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1574266328 linked to?

On MyGeneLog this position is linked to Febrile Seizures. The research behind each link, and its sources, are set out on that condition page.

Does having rs1574266328 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1574266328 come from?

ClinVar VCV000995993, criteria provided, single submitter. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Generalized epilepsy with febrile seizures plus, type 2 (rs1574266328). MyGeneLog™. https://www.mygenelog.com/variants/rs1574266328

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