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Who was studied 1,022 European ancestry cases, 2,503 European ancestry controls; replicated in 1,387 European ancestry cases, 1,115 European ancestry controls.
The effect
Each copy of the A allele carried 1.35 times the odds of Ulcerative colitis; p = 3 × 10−12.
How common The A allele had a frequency of about 38% in the people studied.
Where it sits Chromosome 12, band 12q15 — in an intron of IFNG-AS1.
What each result means
A/ATwo copies of the version the research linked to Ulcerative colitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Ulcerative colitis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Ulcerative colitis. This is the starting point the study compared everyone against.
Nature genetics · 2009 · PMID 19122664 · open access
Questions about rs1558744
What is rs1558744?
rs1558744 is a single position in the genome, in or near the IFNG gene. Published research associates it with ulcerative colitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1558744 linked to?
On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs1558744 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1558744 come from?
GWAS Catalog, Nat Genet 2009, PMID:19122664. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 4733116223323Reads by AI crawlersClaude3ChatGPT3Google · Gemini1Perplexity1Meta AI6Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others23Total47Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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