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Who was studied 13,708 European ancestry cases, 95,282 European ancestry controls; replicated in 5,353 European ancestry cases, 5,551 European ancestry controls.
The effect
Each copy of the T allele carried 1.11 times the odds of Parkinson's disease (95% confidence interval 1.09-1.14); p = 7 × 10−14.
How common The T allele had a frequency of about 53% in the people studied.
Where it sits Chromosome 14, band 14q24.1 — inside GPHN.
What each result means
A/ANo copy of the version the research linked to Parkinson's disease. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Parkinson's disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Parkinson's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2014 · PMID 25064009 · open access
Questions about rs1555399
What is rs1555399?
rs1555399 is a single position in the genome, in or near the TMEM229B gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1555399 linked to?
On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs1555399 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1555399 come from?
GWAS Catalog, Nat Genet 2014, PMID:25064009. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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