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Who was studied at least 5,919 European ancestry cases, at least 130,691 European ancestry controls; replicated in 634,037 European ancestry cases, 1,308,690 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.0147 lower (95% confidence interval 0.0095-0.0199); p = 2 × 10−10.
How common The C allele had a frequency of about 46% in the people studied.
Where it sits Chromosome 2, band 2p24.1 — in an intron of LINC01830.
What each result means
C/CTwo copies of the version the research linked to Depression. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Depression. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Depression. This is the starting point the study compared everyone against.
rs1554269 is a single position in the genome, in or near the AC068490.2 gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1554269 linked to?
On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.
Does having rs1554269 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1554269 come from?
GWAS Catalog, Nature human behaviour 2021, PMID:33859377. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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