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Psoriasis

near HLA-DMB · rs154973

Where this position leads

Condition: Psoriasis

rs154973 Condition: Psoriasis Psoriasis Condition rs154973 rs154973 near HLA-DMB

What the study found

Who was studied 394,626 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.168 lower (95% confidence interval 0.099-0.237); p = 2 × 10−13.

How common The T allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 1.8 kb from HLA-DMB.

What each result means

C/C No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs154973

What is rs154973?

rs154973 is a single position in the genome, in or near the near HLA-DMB gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs154973 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs154973 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs154973 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs154973). MyGeneLog™. https://www.mygenelog.com/variants/rs154973

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