Standard
Proinsulin levels
LARP6 · rs1549318
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Proinsulin levels — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Proinsulin levels.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Proinsulin levels compared to the general population.
Source
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
Strawbridge RJ,
Dupuis J,
Prokopenko I,
Barker A,
Ahlqvist E,
Rybin D,
Petrie JR,
Travers ME,
Bouatia-Naji N,
Dimas AS,
Nica A,
Wheeler E
and 91 more — show all
Chen H,
Voight BF,
Taneera J,
Kanoni S,
Peden JF,
Turrini F,
Gustafsson S,
Zabena C,
Almgren P,
Barker DJ,
Barnes D,
Dennison EM,
Eriksson JG,
Eriksson P,
Eury E,
Folkersen L,
Fox CS,
Frayling TM,
Goel A,
Gu HF,
Horikoshi M,
Isomaa B,
Jackson AU,
Jameson KA,
Kajantie E,
Kerr-Conte J,
Kuulasmaa T,
Kuusisto J,
Loos RJ,
Luan J,
Makrilakis K,
Manning AK,
Martínez-Larrad MT,
Narisu N,
Nastase Mannila M,
Ohrvik J,
Osmond C,
Pascoe L,
Payne F,
Sayer AA,
Sennblad B,
Silveira A,
Stancáková A,
Stirrups K,
Swift AJ,
Syvänen AC,
Tuomi T,
van 't Hooft FM,
Walker M,
Weedon MN,
Xie W,
Zethelius B,
Ongen H,
Mälarstig A,
Hopewell JC,
Saleheen D,
Chambers J,
Parish S,
Danesh J,
Kooner J,
Ostenson CG,
Lind L,
Cooper CC,
Serrano-Ríos M,
Ferrannini E,
Forsen TJ,
Clarke R,
Franzosi MG,
Seedorf U,
Watkins H,
Froguel P,
Johnson P,
Deloukas P,
Collins FS,
Laakso M,
Dermitzakis ET,
Boehnke M,
McCarthy MI,
Wareham NJ,
Groop L,
Pattou F,
Gloyn AL,
Dedoussis GV,
Lyssenko V,
Meigs JB,
Barroso I,
Watanabe RM,
Ingelsson E,
Langenberg C,
Hamsten A,
Florez JC
Diabetes · 2011 · PMID 21873549 · open access
Questions about rs1549318
What is rs1549318?
rs1549318 is a single position in the genome, in or near the LARP6 gene. Published research associates it with proinsulin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1549318 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1549318 come from?
GWAS Catalog, Diabetes 2011, PMID:21873549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants