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Chronic dry cough or cough in response to angiotensin-converting enzyme inhibitor drugs

near SRBD1 · rs1544730

What the study found

Who was studied 226 African ancestry cases, 1,061 African ancestry controls, 27,772 European ancestry cases, 141,390 European ancestry controls, 32 East Asian ancestry cases, 116 East Asian ancestry controls, 1,057 South Asian ancestry cases, 8,532 South Asian ancestry controls, 71 cases, 123 controls.

The effect Each copy of the A allele carried 1.11 times the odds of Chronic dry cough or cough in response to angiotensin-converting enzyme inhibitor drugs (95% confidence interval 1.1-1.16); p = 2 × 10−16.

How common The A allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 2, band 2p21 — between genes, 27.8 kb from SRBD1.

What each result means

A/A Two copies of the version the research linked to Chronic dry cough or cough in response to angiotensin-converting enzyme inhibitor drugs. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Chronic dry cough or cough in response to angiotensin-converting enzyme inhibitor drugs. That is a smaller link than two copies.
G/G No copy of the version the research linked to Chronic dry cough or cough in response to angiotensin-converting enzyme inhibitor drugs. This is the starting point the study compared everyone against.
Source

Questions about rs1544730

What is rs1544730?

rs1544730 is a single position in the genome, in or near the near SRBD1 gene. Published research associates it with chronic dry cough or cough in response to angiotensin-converting enzyme inhibitor drugs. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1544730 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1544730 come from?

GWAS Catalog, The European respiratory journal 2025, PMID:40675770. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Chronic dry cough or cough in response to angiotensin-converting enzyme inhibitor drugs (rs1544730). MyGeneLog™. https://www.mygenelog.com/variants/rs1544730

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