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Non-ischemic heart failure

CARM1 · rs1541596

Where this position leads

What the study found

Who was studied 11,742 European ancestry cases, 691,259 European ancestry controls, 11,122 East Asian ancestry cases, 171,995 East Asian ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0603 higher (95% confidence interval 0.039-0.082); p = 3 × 10⁻⁸.

How common The G allele had a frequency of about 61% in the people studied.

Where it sits Chromosome 19, band 19p13.2 — in an intron of CARM1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Non-ischemic heart failure — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Non-ischemic heart failure.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Non-ischemic heart failure compared to the general population.

Source

Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population

Enzan N, Miyazawa K, Koyama S, Kurosawa R, Ieki H, Yoshida H, Takechi F, Fukuyama M, Osako R, Tomizuka K, Liu X, Ozaki K

and 18 more — show all

Onouchi Y, Matsuda K, Momozawa Y, Aburatani H, Kamatani Y, Yamaguchi T, Akazawa H, Node K, Ellinor PT, Levin MG, Damrauer SM, Voight BF, Joseph J, Sun YV, Terao C, Ninomiya T, Komuro I, Ito K

BioBank Japan Project

Nature communications · 2025 · PMID 41184235 · open access

Questions about rs1541596

What is rs1541596?

rs1541596 is a single position in the genome, in or near the CARM1 gene. Published research associates it with non-ischemic heart failure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1541596 linked to?

On MyGeneLog this position is linked to Heart Failure. The research behind each link, and its sources, are set out on that condition page.

Does having rs1541596 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1541596 come from?

GWAS Catalog, Nature communications 2025, PMID:41184235. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Non-ischemic heart failure (rs1541596). MyGeneLog™. https://www.mygenelog.com/variants/rs1541596

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