Peripheral artery disease or LDL cholesterol (pleiotropy)
PCSK6 · rs1531817
0 00Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total0Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 24,009 European ancestry peripherial artery disease cases, 723000 (all lipid traits) cases.
The effect
The reported allele is C; the catalogue records no effect size
; p = 3 × 10−10.
How common The C allele had a frequency of about 68% in the people studied.
Where it sits Chromosome 15, band 15q26.3 — in an intron of PCSK6.
What each result means
A/ANo copy of the version the research linked to Peripheral artery disease or LDL cholesterol (pleiotropy). This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Peripheral artery disease or LDL cholesterol (pleiotropy). That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Peripheral artery disease or LDL cholesterol (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
Frontiers in genetics · 2021 · PMID 35186008 · open access
Questions about rs1531817
What is rs1531817?
rs1531817 is a single position in the genome, in or near the PCSK6 gene. Published research associates it with peripheral artery disease or ldl cholesterol (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1531817 linked to?
On MyGeneLog this position is linked to Peripheral Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs1531817 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1531817 come from?
GWAS Catalog, Frontiers in genetics 2021, PMID:35186008. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 00Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total0Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Peripheral artery disease or LDL cholesterol (pleiotropy) (rs1531817). MyGeneLog™. https://www.mygenelog.com/variants/rs1531817