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Body mass index

ROBO2 · rs1523768

Where this position leads

Condition: Obesity and Body Weight

rs1523768 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs1523768 rs1523768 ROBO2

What the study found

Who was studied 806,834 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0126 lower (95% confidence interval 0.0093-0.0159); p = 4 × 10−13.

How common The A allele had a frequency of about 67% in the people studied.

Where it sits Chromosome 3, band 3p12.3 — in an intron of ROBO2.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.
G/G Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.
Source
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry
Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, Yang J, Jones S
and 10 more — show all
Beaumont R, Croteau-Chonka DC, Winkler TW, Hattersley AT, Loos RJF, Hirschhorn JN, Visscher PM, Frayling TM, Yaghootkar H, Lindgren CM
GIANT Consortium
Human molecular genetics · 2019 · PMID 30239722 · open access

Questions about rs1523768

What is rs1523768?

rs1523768 is a single position in the genome, in or near the ROBO2 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1523768 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs1523768 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1523768 come from?

GWAS Catalog, Hum Mol Genet 2018, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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