0 6222Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot2Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 12,395 European ancestry cases, 287,787 European ancestry controls, 1,445 black cases, 79,299 black controls, 611 Hispanic cases, 31,458 Hispanic controls; replicated in 11,433 European ancestry cases, 254,839 European ancestry controls, 1,110 black cases, 64,397 black controls, 346 Hispanic cases, 28,858 Hispanic controls.
The effect
Each copy of the A allele carried 1.08 times the odds of Calcific aortic valve stenosis (95% confidence interval 1.05-1.1); p = 1 × 10−8.
Where it sits Chromosome 3, band 3p14.3 — between genes, 18.1 kb from PPIAP16.
What each result means
A/ATwo copies of the version the research linked to Calcific aortic valve stenosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Calcific aortic valve stenosis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Calcific aortic valve stenosis. This is the starting point the study compared everyone against.
rs1522387 is a single position in the genome, in or near the near PPIAP16 gene. Published research associates it with calcific aortic valve stenosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1522387 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1522387 come from?
GWAS Catalog, Circulation 2023, PMID:36802703. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 6222Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot2Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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