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Who was studied 4,502 Danish ancestry cases, 51,049 Danish ancestry controls; replicated in 3,133 European ancestry cases, 32,917 European ancestry controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 1 × 10−10.
Where it sits Chromosome 1, band 1q32.1 — in an intron of IL10.
What ClinVar records
ClassificationBenign for Inflammatory bowel disease; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2026-01-26.
ClinVar record 1166835NM_000572.3(IL10):c.225+56A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Febrile seizures. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Febrile seizures. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Febrile seizures. That is the strongest link of the three results. A link in a study is not a diagnosis.
Brain : a journal of neurology · 2022 · PMID 35022648 · open access
Questions about rs1518111
What is rs1518111?
rs1518111 is a single position in the genome, in or near the IL10 gene. Published research associates it with febrile seizures. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1518111 linked to?
On MyGeneLog this position is linked to Febrile Seizures. The research behind each link, and its sources, are set out on that condition page.
Does having rs1518111 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1518111 come from?
GWAS Catalog, Brain : a journal of neurology 2022, PMID:35022648. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 132128Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple1China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others8Total13Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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