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Its strongest genetic-study result is p = 10−11, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied up to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls; replicated in up to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls.
The effect
Each copy of the T allele carried 1.15 times the odds of Rheumatoid arthritis (95% confidence interval 1.10-1.20); p = 1 × 10−10.
How common The T allele had a frequency of about 89% in the people studied.
Where it sits Chromosome 8, band 8q24.21 — in an intron of LINC00824.
How common each version is
CT
KoreanKRGDB
C 4.4% · T 95.6%
KoreanKorea4K
C 3.4% · T 96.7%
Japanese ToMMo
C 2.5% · T 97.5%
Vietnamese
C 0.9% · T 99.1%
World gnomAD
C 18.4% · T 81.6%
World 1000 Genomes
C 15.7% · T 84.3%
World TOPMed
C 18.9% · T 81.1%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
C/CNo copy of the version the research linked to Rheumatoid arthritis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Rheumatoid arthritis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Rheumatoid arthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs1516971 is a single position in the genome, in or near the PVT1 gene. Published research associates it with rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1516971 linked to?
On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs1516971 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1516971 come from?
GWAS Catalog, Nature 2013, PMID:24390342. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 3322113223116Reads by AI crawlersClaude2ChatGPT2Google · Gemini1Perplexity1Meta AI3Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others16Total33Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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