The effect
Each copy of the T allele carried 4.18 times the odds of Diarrhoea in darapladib-treated cardiovascular disease (time to event) (95% confidence interval 2.63-6.67); p = 2 × 10−9.
How common The T allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 16, band 16q23.1 — in an intron of TMEM231.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Diarrhoea in darapladib-treated cardiovascular disease (time to event) — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Diarrhoea in darapladib-treated cardiovascular disease (time to event).
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Diarrhoea in darapladib-treated cardiovascular disease (time to event) compared to the general population.
rs151269874 is a single position in the genome, in or near the RP11-77K12.8 gene. Published research associates it with diarrhoea in darapladib-treated cardiovascular disease (time to event). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs151269874 linked to?
On MyGeneLog this position is linked to Darapladib Response in Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs151269874 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs151269874 come from?
GWAS Catalog, PLoS One 2017, PMID:28753643. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.