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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 2,466 Black/admixed ancestry individuals; replicated in up to 1,653 European, Hispanic, Asian or Black individuals.
The effect
Each copy of the T allele shifted the measure 1.02 higher (95% confidence interval 0.72-1.32); p = 4 × 10−11.
Where it sits Chromosome 5, band 5p15.33 — a missense change in SDHA.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Succinic acid/Methylmalonic acid levels — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Succinic acid/Methylmalonic acid levels.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Succinic acid/Methylmalonic acid levels compared to the general population.
Nature communications · 2022 · PMID 35995766 · open access
Questions about rs151266052
What is rs151266052?
rs151266052 is a single position in the genome, in or near the SDHA gene. Published research associates it with succinic acid/methylmalonic acid levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs151266052 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs151266052 come from?
GWAS Catalog, Nature communications 2022, PMID:35995766. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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