PCSK9 · rs151193009
Where this position leads
Condition: Cholesterol (LDL, HDL and Total)
What the study found
Who was studied 6,949 Korean ancestry individuals; replicated in 6,000 Korean ancestry individuals.
The effect Each copy of the T allele shifted the measure 19.4 lower (95% confidence interval 14.33-24.48); p = 8 × 10−14.
How common The T allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 1, band 1p32.3 — a missense change in PCSK9.
What ClinVar records
Classification
Conflicting classifications of pathogenicity for Hypercholesterolemia, autosomal dominant, 3, Hypercholesterolemia, familial, 1, Familial hypercholesterolemia; criteria provided, conflicting classifications (1 of 4 stars, 10 submitters), last evaluated 2026-01-27.
ClinVar record 413319 NM_174936.4(PCSK9):c.277C>T (p.Arg93Cys)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs151193009 is a single position in the genome, in or near the PCSK9 gene. Published research associates it with total cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Sci Rep 2019, PMID:30718733. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Total cholesterol levels (rs151193009). MyGeneLog™. https://www.mygenelog.com/variants/rs151193009