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Chronic lung diseases including COPD, Emphysema and Bronchitis

CHRNA4 · rs151176846

Where this position leads

Condition: Chronic Obstructive Pulmonary Disease (COPD)

rs151176846 Condition: Chronic Obstructive Pulmonary Disease (COPD) Chronic Obstructive Pulmonary Disea… Condition rs151176846 rs151176846 CHRNA4

What the study found

Who was studied 38,732 European ancestry cases, 276,936 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.122 lower (95% confidence interval 0.093-0.151); p = 2 × 10−17.

How common The T allele had a frequency of about 92% in the people studied.

Where it sits Chromosome 20, band 20q13.33 — in an intron of CHRNA4.

What each result means

C/C No copy of the version the research linked to Chronic lung diseases including COPD, Emphysema and Bronchitis. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Chronic lung diseases including COPD, Emphysema and Bronchitis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Chronic lung diseases including COPD, Emphysema and Bronchitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs151176846

What is rs151176846?

rs151176846 is a single position in the genome, in or near the CHRNA4 gene. Published research associates it with chronic lung diseases including copd, emphysema and bronchitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs151176846 linked to?

On MyGeneLog this position is linked to Chronic Obstructive Pulmonary Disease (COPD). The research behind each link, and its sources, are set out on that condition page.

Does having rs151176846 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs151176846 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Chronic lung diseases including COPD, Emphysema and Bronchitis (rs151176846). MyGeneLog™. https://www.mygenelog.com/variants/rs151176846

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