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IL12B protein levels

IL12B-AS1 · rs151160735

Where this position leads

Condition: Celiac Disease

rs151160735 Condition: Celiac Disease Celiac Disease Condition rs151160735 rs151160735 IL12B-AS1

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.312 lower (95% confidence interval 0.26-0.36); p = 1 × 10−43.

How common The G allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 5, band 5q33.3 — inside IL12B-AS1.

What each result means

G/G Two copies of the version the research linked to IL12B protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to IL12B protein levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to IL12B protein levels. This is the starting point the study compared everyone against.
Source

Questions about rs151160735

What is rs151160735?

rs151160735 is a single position in the genome, in or near the IL12B-AS1 gene. Published research associates it with il12b protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs151160735 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs151160735 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs151160735 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

IL12B protein levels (rs151160735). MyGeneLog™. https://www.mygenelog.com/variants/rs151160735

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