0 102224Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others4Total10Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 449,734 European ancestry individuals; replicated in 248,098 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.159 lower (95% confidence interval 0.14-0.18); p = 7 × 10−40.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 1, band 1p36.23 — a missense change in PER3.
What ClinVar records
ClassificationConflicting classifications of pathogenicity for Advanced sleep phase syndrome 3; criteria provided, conflicting classifications (1 of 4 stars, 4 submitters), last evaluated 2025-02-16.
ClinVar record 242410NM_001377275.1(PER3):c.1243C>G (p.Pro415Ala)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CTwo copies of the version the research linked to Chronotype. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Chronotype. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Chronotype. This is the starting point the study compared everyone against.
Nature communications · 2019 · PMID 30696823 · open access
Questions about rs150812083
What is rs150812083?
rs150812083 is a single position in the genome, in or near the PER3 gene. Published research associates it with chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs150812083 linked to?
On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.
Does having rs150812083 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs150812083 come from?
GWAS Catalog, Nature communications 2019, PMID:30696823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 102224Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others4Total10Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.