Standard

Cerebrospinal fluid AB1-42 levels

SPATA8 · rs1503351

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied up to 189 European and other ancestry early mild cognitive impairment cases, up to 251 European and other ancestry late mild cognitive impairment cases, up to 121 European and other ancestry Alzheimer's disease cases, up to 215 European and other ancestry healthy controls; replicated in up to 3 European and other ancestry significant memory concern cases, up to 57 European and other ancestry early mild cognitive impairment cases, up to 61 European and other ancestry late mild cognitive impairment cases, up to 62 European and other ancestry Alzheimer's disease cases, up to 21 European and other ancestry healthy controls.

The effect Each copy of the A allele shifted the measure 0.17 higher; p = 4 × 10⁻⁸.

How common The A allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 15, band 15q26.2 — between genes, 27.8 kb from RN7SKP181.

What each result means

A/A Two copies of the version the research linked to Cerebrospinal fluid AB1-42 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Cerebrospinal fluid AB1-42 levels. That is a smaller link than two copies.

G/G No copy of the version the research linked to Cerebrospinal fluid AB1-42 levels. This is the starting point the study compared everyone against.

Source

Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level

Li QS, Parrado AR, Samtani MN, Narayan VA

Alzheimer’s Disease Neuroimaging Initiative

PloS one · 2015 · PMID 26252872 · open access

Questions about rs1503351

What is rs1503351?

rs1503351 is a single position in the genome, in or near the SPATA8 gene. Published research associates it with cerebrospinal fluid ab1-42 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1503351 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1503351 come from?

GWAS Catalog, PLoS One 2015, PMID:26252872. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cerebrospinal fluid AB1-42 levels (rs1503351). MyGeneLog™. https://www.mygenelog.com/variants/rs1503351

← See all variants