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Glycated hemoglobin in pregnancy

GAB3 · rs150109313

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 66,799 Chinese ancestry individuals; replicated in 45,280 Chinese ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.421 lower (95% confidence interval 0.33-0.51); p = 3 × 10⁻²⁰.

How common The G allele had a frequency of about 1% in the people studied.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Glycated hemoglobin in pregnancy — no copies of the reported risk allele.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Glycated hemoglobin in pregnancy.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Glycated hemoglobin in pregnancy compared to the general population.

Source

Genome-wide association analyses of gestational phenotypes identify context-specific genetic effects

Liu S, Zheng H, Gu Y, Yang Z, Zhen J, Wei Y, Liu Y, Chen Y, Wan Z, Guo X, Hu L, Chen X

and 11 more — show all

Li X, Qiu X, Huang S, Chen GB, Hu Z, Namba S, Kanai M, Matsuda K, Okada Y, Zhang Q, Wei F

Nature genetics · 2026 · PMID 42509370

Questions about rs150109313

What is rs150109313?

rs150109313 is a single position in the genome, in or near the GAB3 gene. Published research associates it with glycated hemoglobin in pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs150109313 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs150109313 come from?

GWAS Catalog, Nature genetics 2026, PMID:42509370. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Glycated hemoglobin in pregnancy (rs150109313). MyGeneLog™. https://www.mygenelog.com/variants/rs150109313

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