GREB1 · rs149940960
Where this position leads
Condition: Acute Lymphoblastic Leukemia
What the study found
Who was studied up to 488 European ancestry cases, up to 111 African American cases, up to 60 Hispanic cases, up to 56 other ancestry cases.
The effect Each copy of the T allele carried 6.67 times the odds of Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (95% confidence interval 1.49-25); p = 2 × 10−8.
Where it sits Chromosome 2, band 2p25.1 — in the 3′ untranslated region of GREB1.
rs149940960 is a single position in the genome, in or near the GREB1 gene. Published research associates it with alanine aminotransferase (alt) levels after remission induction therapy in actute lymphoblastic leukemia (all). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Acute Lymphoblastic Leukemia. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Clin Pharmacol Ther 2017, PMID:28090653. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (rs149940960). MyGeneLog™. https://www.mygenelog.com/variants/rs149940960