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Body mass index

VPS13C · rs149869681

Where this position leads

Conditions: Childhood Body Mass Index, Obesity and Body Weight

rs149869681 Condition: Childhood Body Mass Index Childhood Body Mass Index Condition Condition: Obesity and Body Weight Obesity and Body Weight Condition rs149869681 rs149869681 VPS13C

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0282 lower (95% confidence interval 0.024-0.033); p = 1 × 10−34.

Where it sits Chromosome 15, band 15q22.2 — in an intron of VPS13C.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.
Source
Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures
Jee YH, Wang Y, Jung KJ, Lee JY, Kimm H, Duan R, Price AL, Martin AR, Kraft P
Nature communications · 2025 · PMID 40436827 · open access

Questions about rs149869681

What is rs149869681?

rs149869681 is a single position in the genome, in or near the VPS13C gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs149869681 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index, Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs149869681 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs149869681 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Body mass index (rs149869681). MyGeneLog™. https://www.mygenelog.com/variants/rs149869681

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