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PRG3 protein levels

SLC43A3 · rs149820828

Where this position leads

Condition: Celiac Disease

rs149820828 Condition: Celiac Disease Celiac Disease Condition rs149820828 rs149820828 SLC43A3

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.166 lower (95% confidence interval 0.11-0.22); p = 2 × 10−12.

How common The C allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 11, band 11q12.1 — in an intron of SLC43A3.

What each result means

C/C Two copies of the version the research linked to PRG3 protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to PRG3 protein levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to PRG3 protein levels. This is the starting point the study compared everyone against.
Source

Questions about rs149820828

What is rs149820828?

rs149820828 is a single position in the genome, in or near the SLC43A3 gene. Published research associates it with prg3 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs149820828 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs149820828 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs149820828 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

PRG3 protein levels (rs149820828). MyGeneLog™. https://www.mygenelog.com/variants/rs149820828

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