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Sphingomyelin(32:1)_[M+H]1+ levels

SYNE2 · rs149809141

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10⁻²³, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 5,662 Pakistani ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.121 higher (95% confidence interval 0.097-0.144); p = 5 × 10⁻²⁴.

Where it sits Chromosome 14, band 14q23.2 — in an intron of SYNE2.

What each result means

A/A Two copies of the version the research linked to Sphingomyelin(32:1)_[M+H]1+ levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Sphingomyelin(32:1)_[M+H]1+ levels. That is a smaller link than two copies.

G/G No copy of the version the research linked to Sphingomyelin(32:1)_[M+H]1+ levels. This is the starting point the study compared everyone against.

Source

Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci

Harshfield EL, Fauman EB, Stacey D, Paul DS, Ziemek D, Ong RMY, Danesh J, Butterworth AS, Rasheed A, Sattar T, Zameer-Ul-Asar, Saleem I

and 18 more — show all

Hina Z, Ishtiaq U, Qamar N, Mallick NH, Yaqub Z, Saghir T, Rizvi SNH, Memon A, Ishaq M, Rasheed SZ, Memon FU, Jalal A, Abbas S, Frossard P, Saleheen D, Wood AM, Griffin JL, Koulman A

BMC medicine · 2021 · PMID 34503513 · open access

Questions about rs149809141

What is rs149809141?

rs149809141 is a single position in the genome, in or near the SYNE2 gene. Published research associates it with sphingomyelin(32:1)_[m+h]1+ levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs149809141 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs149809141 come from?

GWAS Catalog, BMC medicine 2021, PMID:34503513. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Sphingomyelin(32:1)_[M+H]1+ levels (rs149809141). MyGeneLog™. https://www.mygenelog.com/variants/rs149809141

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