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GDF15 protein levels

near PGPEP1 · rs149520967

Where this position leads

Condition: Celiac Disease

rs149520967 Condition: Celiac Disease Celiac Disease Condition rs149520967 rs149520967 near PGPEP1

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.1 higher (95% confidence interval 0.069-0.131); p = 1 × 10−11.

How common The T allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 19, band 19p13.11 — between genes, 0.8 kb from PGPEP1.

What each result means

C/C No copy of the version the research linked to GDF15 protein levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to GDF15 protein levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to GDF15 protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs149520967

What is rs149520967?

rs149520967 is a single position in the genome, in or near the near PGPEP1 gene. Published research associates it with gdf15 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs149520967 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs149520967 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs149520967 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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GDF15 protein levels (rs149520967). MyGeneLog™. https://www.mygenelog.com/variants/rs149520967

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