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Red blood cell count

OR52E3P · rs149371331

Where this position leads

Condition: Blood Cell Counts

rs149371331 Condition: Blood Cell Counts Blood Cell Counts Condition rs149371331 rs149371331 OR52E3P

What the study found

Who was studied 20,220 Amish, White ancestry individuals, 384 Asian ancestry individuals, 10,747 Black individuals, 13,119 Central American ancestry, Cuban ancestry, Dominican ancestry, Mexican ancestry, Puerto Rican ancestry, South American ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.23 higher (95% confidence interval 0.17-0.29); p = 3 × 10−18.

Where it sits Chromosome 11, band 11p15.4 — in a non-coding transcript of OR52E3P.

What each result means

A/A Two copies of the version the research linked to Red blood cell count. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Red blood cell count. That is a smaller link than two copies.
C/C No copy of the version the research linked to Red blood cell count. This is the starting point the study compared everyone against.
Source
Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program
Hu Y, Stilp AM, McHugh CP, Rao S, Jain D, Zheng X, Lane J, Méric de Bellefon S, Raffield LM, Chen MH, Yanek LR, Wheeler M
and 67 more — show all
Yao Y, Ren C, Broome J, Moon JY, de Vries PS, Hobbs BD, Sun Q, Surendran P, Brody JA, Blackwell TW, Choquet H, Ryan K, Duggirala R, Heard-Costa N, Wang Z, Chami N, Preuss MH, Min N, Ekunwe L, Lange LA, Cushman M, Faraday N, Curran JE, Almasy L, Kundu K, Smith AV, Gabriel S, Rotter JI, Fornage M, Lloyd-Jones DM, Vasan RS, Smith NL, North KE, Boerwinkle E, Becker LC, Lewis JP, Abecasis GR, Hou L, O'Connell JR, Morrison AC, Beaty TH, Kaplan R, Correa A, Blangero J, Jorgenson E, Psaty BM, Kooperberg C, Walton RT, Kleinstiver BP, Tang H, Loos RJF, Soranzo N, Butterworth AS, Nickerson D, Rich SS, Mitchell BD, Johnson AD, Auer PL, Li Y, Mathias RA, Lettre G, Pankratz N, Laurie CC, Laurie CA, Bauer DE, Conomos MP, Reiner AP
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
American journal of human genetics · 2021 · PMID 33887194

Questions about rs149371331

What is rs149371331?

rs149371331 is a single position in the genome, in or near the OR52E3P gene. Published research associates it with red blood cell count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs149371331 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs149371331 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs149371331 come from?

GWAS Catalog, American journal of human genetics 2021, PMID:33887194. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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Red blood cell count (rs149371331). MyGeneLog™. https://www.mygenelog.com/variants/rs149371331

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