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Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms

LPA · rs149302195

Where this position leads

What the study found

Who was studied 13,781 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 10.1 lower (95% confidence interval 7.57-12.71); p = 2 × 10⁻¹⁷.

Where it sits Chromosome 6, band 6q25.3 — in an intron of SLC22A3.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms compared to the general population.

Source

A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms

Mack S, Coassin S, Rueedi R, Yousri NA, Seppälä I, Gieger C, Schönherr S, Forer L, Erhart G, Marques-Vidal P, Ried JS, Waeber G

and 15 more — show all

Bergmann S, Dähnhardt D, Stöckl A, Raitakari OT, Kähönen M, Peters A, Meitinger T, Strauch K, Kedenko L, Paulweber B, Lehtimäki T, Hunt SC, Vollenweider P, Lamina C, Kronenberg F

Journal of lipid research · 2017 · PMID 28512139 · open access

Questions about rs149302195

What is rs149302195?

rs149302195 is a single position in the genome, in or near the LPA gene. Published research associates it with lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs149302195 linked to?

On MyGeneLog this position is linked to Lipoprotein(a) Levels. The research behind each link, and its sources, are set out on that condition page.

Does having rs149302195 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs149302195 come from?

GWAS Catalog, J Lipid Res 2017, PMID:28512139. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms (rs149302195). MyGeneLog™. https://www.mygenelog.com/variants/rs149302195

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