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Platelet count

ZSWIM6 · rs149262078

Where this position leads

Conditions: Blood Cell Counts, Colon Polyp

rs149262078 Condition: Blood Cell Counts Blood Cell Counts Condition Condition: Colon Polyp Colon Polyp Condition rs149262078 rs149262078 ZSWIM6

What the study found

Who was studied 350,474 European ancestry individuals, 148,623 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0498 higher (95% confidence interval 0.041-0.059); p = 2 × 10−28.

Where it sits Chromosome 5, band 5q12.1 — in an intron of ZSWIM6.

What each result means

C/C No copy of the version the research linked to Platelet count. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Platelet count. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Platelet count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs149262078

What is rs149262078?

rs149262078 is a single position in the genome, in or near the ZSWIM6 gene. Published research associates it with platelet count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs149262078 linked to?

On MyGeneLog this position is linked to Blood Cell Counts, Colon Polyp. The research behind each link, and its sources, are set out on that condition page.

Does having rs149262078 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs149262078 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Platelet count (rs149262078). MyGeneLog™. https://www.mygenelog.com/variants/rs149262078

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