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High-sensitivity C-reactive protein levels

SPPL3 · rs149156910

Where this position leads

Condition: C-Reactive Protein Levels

rs149156910 Condition: C-Reactive Protein Levels C-Reactive Protein Levels Condition rs149156910 rs149156910 SPPL3

What the study found

Who was studied 71,019 Korean ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0695 lower (95% confidence interval 0.048-0.091); p = 4 × 10−10.

How common The G allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 12, band 12q24.31 — in an intron of SPPL3.

What each result means

A/A No copy of the version the research linked to High-sensitivity C-reactive protein levels. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to High-sensitivity C-reactive protein levels. That is a smaller link than two copies.
G/G Two copies of the version the research linked to High-sensitivity C-reactive protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs149156910

What is rs149156910?

rs149156910 is a single position in the genome, in or near the SPPL3 gene. Published research associates it with high-sensitivity c-reactive protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs149156910 linked to?

On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.

Does having rs149156910 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs149156910 come from?

GWAS Catalog, Scientific reports 2025, PMID:39747571. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

High-sensitivity C-reactive protein levels (rs149156910). MyGeneLog™. https://www.mygenelog.com/variants/rs149156910

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