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Cortical thickness

near DACT1 · rs149142

What the study found

Who was studied 33,992 European ancestry individuals; replicated in 14,727 European ancestry individuals, 2,943 individuals.

The effect Each copy of the T allele shifted the measure 0.00647 lower (95% confidence interval 0.0049-0.008); p = 6 × 10−16.

How common The T allele had a frequency of about 60% in the people studied.

Where it sits Chromosome 14, band 14q23.1 — between genes, 29 kb from DACT1.

What each result means

C/C No copy of the version the research linked to Cortical thickness. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Cortical thickness. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cortical thickness. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs149142

What is rs149142?

rs149142 is a single position in the genome, in or near the near DACT1 gene. Published research associates it with cortical thickness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs149142 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs149142 come from?

GWAS Catalog, Science (New York, N.Y.) 2020, PMID:32193296. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cortical thickness (rs149142). MyGeneLog™. https://www.mygenelog.com/variants/rs149142

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