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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
2 / 4
Its strongest genetic-study result is p = 10−46, with 6 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0942 lower (95% confidence interval 0.081-0.107); p = 4 × 10−47.
How common The C allele had a frequency of about 88% in the people studied.
Where it sits Chromosome 19, band 19p13.2 — inside SMARCA4.
What each result means
C/CTwo copies of the version the research linked to Triglycerides to total lipids ratio in large VLDL. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Triglycerides to total lipids ratio in large VLDL. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Triglycerides to total lipids ratio in large VLDL. This is the starting point the study compared everyone against.
rs148898583 is a single position in the genome, in or near the SMARCA4 gene. Published research associates it with triglycerides to total lipids ratio in large vldl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs148898583 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs148898583 come from?
GWAS Catalog, Nature 2024, PMID:38448586. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Triglycerides to total lipids ratio in large VLDL (rs148898583). MyGeneLog™. https://www.mygenelog.com/variants/rs148898583