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Appendicular lean mass

STC2 · rs148833559

What the study found

Who was studied 450,243 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.38 higher (95% confidence interval 0.33-0.43); p = 9 × 10−52.

How common The A allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 5, band 5q35.2 — a missense change in STC2.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Appendicular lean mass compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Appendicular lean mass.
C/C Published research associates this genotype with typical/baseline likelihood of Appendicular lean mass — no copies of the reported risk allele.
Source

Questions about rs148833559

What is rs148833559?

rs148833559 is a single position in the genome, in or near the STC2 gene. Published research associates it with appendicular lean mass. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs148833559 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs148833559 come from?

GWAS Catalog, Commun Biol 2020, PMID:33097823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Appendicular lean mass (rs148833559). MyGeneLog™. https://www.mygenelog.com/variants/rs148833559

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