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Generalized pustular psoriasis

IL36RN · rs148755083

Where this position leads

What the study found

Who was studied 161 Chinese Han ancestry cases, 364 Chinese Han ancestry controls; replicated in 60 Chinese Han ancestry cases, 100 Chinese Han ancestry controls.

The effect Each copy of the C allele carried 8.24 times the odds of Generalized pustular psoriasis (95% confidence interval 4.89-13.9); p = 1 × 10⁻¹⁸.

How common The C allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 2, band 2q14.1 — inside IL36RN.

What ClinVar records

Classification Pathogenic/Likely pathogenic for Generalized pustular psoriasis, Autoinflammatory syndrome, Acrodermatitis continua suppurativa of Hallopeau, IL36RN-related disorder, Type 2 diabetes mellitus; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 13 submitters), last evaluated 2026-02-01. ClinVar record 40005 NM_012275.3(IL36RN):c.115+6T>C

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Two copies of the version the research linked to Generalized pustular psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Generalized pustular psoriasis. That is a smaller link than two copies.

T/T No copy of the version the research linked to Generalized pustular psoriasis. This is the starting point the study compared everyone against.

Source

Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population

Zhang Q, Shi P, Wang Z, Sun L, Li W, Zhao Q, Liu T, Pan Q, Sun Y, Jia F, Chen W, Fu X

and 10 more — show all

Yu G, Bao F, Mi Z, Wang C, Sun Y, Li B, Liu J, Liu H, Gu H, Zhang F

The Journal of investigative dermatology · 2023 · PMID 36804966

Questions about rs148755083

What is rs148755083?

rs148755083 is a single position in the genome, in or near the IL36RN gene. Published research associates it with generalized pustular psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs148755083 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs148755083 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs148755083 come from?

GWAS Catalog, The Journal of investigative dermatology 2023, PMID:36804966. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Generalized pustular psoriasis (rs148755083). MyGeneLog™. https://www.mygenelog.com/variants/rs148755083

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