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Morning vs. evening chronotype

FAT1 · rs148750727

Where this position leads

Condition: Sleep and Circadian Rhythm

rs148750727 Condition: Sleep and Circadian Rhythm Sleep and Circadian Rhythm Condition rs148750727 rs148750727 FAT1

What the study found

Who was studied 8,724 European ancestry evening chronotype individuals, 26,948 European ancestry morning chronotype individuals.

The effect Each copy of the T allele carried 2.34 times the odds of Morning vs. evening chronotype (95% confidence interval 1.69-3.23); p = 2 × 10−8.

How common The T allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 4, band 4q35.2 — between genes, 25.2 kb from LOC124900878.

What each result means

G/G No copy of the version the research linked to Morning vs. evening chronotype. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Morning vs. evening chronotype. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Morning vs. evening chronotype. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs148750727

What is rs148750727?

rs148750727 is a single position in the genome, in or near the FAT1 gene. Published research associates it with morning vs. evening chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs148750727 linked to?

On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.

Does having rs148750727 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs148750727 come from?

GWAS Catalog, Nat Commun 2016, PMID:26955885. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Morning vs. evening chronotype (rs148750727). MyGeneLog™. https://www.mygenelog.com/variants/rs148750727

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