Sensitive

Alzheimer's disease or educational attainment (pleiotropy)

RHOA · rs148734725

Where this position leads

Condition: Alzheimer's Disease

rs148734725 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs148734725 rs148734725 RHOA

What the study found

Who was studied (see Lambert 2013 and Okbay 2016).

The effect Each copy of the A allele shifted the measure 106 z score higher; p = 5 × 10−22.

How common The A allele had a frequency of about 31% in the people studied.

Where it sits Chromosome 3, band 3p21.31 — in an intron of RHOA.

What each result means

A/A Two copies of the version the research linked to Alzheimer's disease or educational attainment (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Alzheimer's disease or educational attainment (pleiotropy). That is a smaller link than two copies.
G/G No copy of the version the research linked to Alzheimer's disease or educational attainment (pleiotropy). This is the starting point the study compared everyone against.
Source

Questions about rs148734725

What is rs148734725?

rs148734725 is a single position in the genome, in or near the RHOA gene. Published research associates it with alzheimer's disease or educational attainment (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs148734725 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs148734725 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs148734725 come from?

GWAS Catalog, GeroScience 2022, PMID:34743297. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease or educational attainment (pleiotropy) (rs148734725). MyGeneLog™. https://www.mygenelog.com/variants/rs148734725

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