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Body mass index

EYS · rs148546399

Where this position leads

Conditions: Obesity and Body Weight, Childhood Body Mass Index

rs148546399 Condition: Obesity and Body Weight Obesity and Body Weight Condition Condition: Childhood Body Mass Index Childhood Body Mass Index Condition rs148546399 rs148546399 EYS

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied up to 72,390 Japanese ancestry women, up to 85,894 Japanese ancestry men; replicated in up to 10,048 Japanese ancestry women, up to 5,098 Japanese ancestry men, up to 181,999 European ancestry women, up to 140,155 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.05 higher (95% confidence interval 0.034-0.066); p = 1 × 10−9.

How common The A allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 6, band 6q12 — in an intron of EYS.

What each result means

A/A Two copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Body mass index. That is a smaller link than two copies.
G/G No copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
Source
Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Iwasaki M, Yamaji T
and 10 more — show all
Sawada N, Hachiya T, Tanno K, Shimizu A, Hozawa A, Minegishi N, Tsugane S, Yamamoto M, Kubo M, Kamatani Y
Nature genetics · 2017 · PMID 28892062

Questions about rs148546399

What is rs148546399?

rs148546399 is a single position in the genome, in or near the EYS gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs148546399 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight, Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.

Does having rs148546399 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs148546399 come from?

GWAS Catalog, Nature genetics 2017, PMID:28892062. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Body mass index (rs148546399). MyGeneLog™. https://www.mygenelog.com/variants/rs148546399

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