Gene Knowledge Graph
UTC
Standard

Uterine fibroids

SORCS3 · rs148482087

Where this position leads

Condition: Uterine Fibroids

rs148482087 Condition: Uterine Fibroids Uterine Fibroids Condition rs148482087 rs148482087 SORCS3

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−18, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 53,711 European ancestry female cases, 380,441 European ancestry female controls, 14,905 East Asian ancestry female cases, 69,609 East Asian ancestry female controls, 14,905 Central Asian ancestry female cases, 69,609 Central Asian ancestry female controls, 14,905 South Asian ancestry female cases, 69,609 South Asian ancestry female controls, 5,678 African ancestry female cases, 15,760 African ancestry female controls.

The effect Each copy of the T allele shifted the measure 0.248 higher (95% confidence interval 0.19-0.3); p = 2 × 10−18.

Where it sits Chromosome 10, band 10q25.1 — in an intron of SORCS3.

What each result means

C/C No copy of the version the research linked to Uterine fibroids. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Uterine fibroids. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Uterine fibroids. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups
Kim J, Williams A, Noh H, Jasper EA, Jones SH, Jaworski JA, Shuey MM, Ruiz-Narváez EA, Wise LA, Palmer JR, Connolly J, Keaton JM
and 11 more — show all
Denny JC, Khan A, Abbass MA, Rasmussen-Torvik LJ, Kottyan LC, Madhivanan P, Krupp K, Wei WQ, Edwards TL, Velez Edwards DR, Hellwege JN
Nature communications · 2025 · PMID 40050615 · open access

Questions about rs148482087

What is rs148482087?

rs148482087 is a single position in the genome, in or near the SORCS3 gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs148482087 linked to?

On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.

Does having rs148482087 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs148482087 come from?

GWAS Catalog, Nature communications 2025, PMID:40050615. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Uterine fibroids (rs148482087). MyGeneLog™. https://www.mygenelog.com/variants/rs148482087

← See all variants