Sensitive

Venous thromboembolism recurrence in pulmonary embolism as first VTE

STXBP5L · rs148458707

Where this position leads

Condition: Venous Thromboembolism

rs148458707 Condition: Venous Thromboembolism Venous Thromboembolism Condition rs148458707 rs148458707 STXBP5L

What the study found

Who was studied 667 European ancestry cases, 2,065 European ancestry controls.

The effect Each copy of the C allele carried 3.46 times the odds of Venous thromboembolism recurrence in pulmonary embolism as first VTE (95% confidence interval 2.304153-5.181975); p = 2 × 10−9.

How common The C allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 3, band 3q13.33 — in an intron of STXBP5L.

What each result means

C/C Two copies of the version the research linked to Venous thromboembolism recurrence in pulmonary embolism as first VTE. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Venous thromboembolism recurrence in pulmonary embolism as first VTE. That is a smaller link than two copies.
T/T No copy of the version the research linked to Venous thromboembolism recurrence in pulmonary embolism as first VTE. This is the starting point the study compared everyone against.
Source

Questions about rs148458707

What is rs148458707?

rs148458707 is a single position in the genome, in or near the STXBP5L gene. Published research associates it with venous thromboembolism recurrence in pulmonary embolism as first vte. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs148458707 linked to?

On MyGeneLog this position is linked to Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.

Does having rs148458707 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs148458707 come from?

GWAS Catalog, Blood 2025, PMID:40811855. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Venous thromboembolism recurrence in pulmonary embolism as first VTE (rs148458707). MyGeneLog™. https://www.mygenelog.com/variants/rs148458707

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