Sensitive

Rate of cognitive decline in Alzheimer's disease

LINC02668 · rs148405458

Where this position leads

Condition: Alzheimer's Disease

rs148405458 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs148405458 rs148405458 LINC02668

What the study found

Who was studied 3,946 European ancestry cases.

The effect Each copy of the C allele shifted the measure 1 lower (95% confidence interval 0.64-1.36); p = 4 × 10−8.

Where it sits Chromosome 10, band 10p15.2 — in an intron of LINC02668.

What each result means

C/C Two copies of the version the research linked to Rate of cognitive decline in Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Rate of cognitive decline in Alzheimer's disease. That is a smaller link than two copies.
T/T No copy of the version the research linked to Rate of cognitive decline in Alzheimer's disease. This is the starting point the study compared everyone against.
Source

Questions about rs148405458

What is rs148405458?

rs148405458 is a single position in the genome, in or near the LINC02668 gene. Published research associates it with rate of cognitive decline in alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs148405458 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs148405458 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs148405458 come from?

GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2020, PMID:32573913. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Rate of cognitive decline in Alzheimer's disease (rs148405458). MyGeneLog™. https://www.mygenelog.com/variants/rs148405458

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