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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 435,563 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 9.95 z score lower; p = 3 × 10−23.
How common The T allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 4, band 4q23 — inside H2AZ1-DT.
What each result means
C/CNo copy of the version the research linked to Problematic alcohol use. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Problematic alcohol use. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Problematic alcohol use. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature neuroscience · 2020 · PMID 32451486 · open access
Questions about rs148382129
What is rs148382129?
rs148382129 is a single position in the genome, in or near the H2AZ1-DT gene. Published research associates it with problematic alcohol use. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs148382129 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs148382129 come from?
GWAS Catalog, Nature neuroscience 2020, PMID:32451486. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Problematic alcohol use (rs148382129). MyGeneLog™. https://www.mygenelog.com/variants/rs148382129